In this report, we analyzed the role of DC IR in the development of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis. We found that EAE was exacerbated in Dcir(-/-) mice associated with severe demyelination of the spinal cords. The number of infiltrated CD11c(+) DC s and CD4(+) T cells into spinal cords was increased in Dcir(-/-) mice. Recall proliferative response of lymph node cells was higher in Dcir(-/-) mice compared with wild-type mice. These observations suggest that DC IR is an important negative regulator of the immune system, and Dcir(-/-) mice should be useful for analyzing the roles of DC IR in an array of autoimmune diseases.
PMID: 25502865 [PubMed - as supplied by publisher] (Source: Experimental Animals)